NFL Schedules
| Date | Week | Away | Home | Score | Venue | Network(s) |
|---|---|---|---|---|---|---|
| Sat, Aug 9 2025 7:30 PM | 2 | Denver Broncos | San Francisco 49ers | - | Levi's Stadium | KPIX, KUSA-TV (9NEWS) |
| Sat, Aug 16 2025 3:05 PM | 3 | San Francisco 49ers | Las Vegas Raiders | - | Allegiant Stadium | Fox 5 Vegas, KPIX, NFL Net |
| Sat, Aug 23 2025 7:30 PM | 4 | Los Angeles Chargers | San Francisco 49ers | - | Levi's Stadium | ESPN Unlmtd, KPIX |
| Sun, Sep 7 2025 3:05 PM | 1 | San Francisco 49ers | Seattle Seahawks | 17 - 13 | Lumen Field | FOX |
| Sun, Sep 14 2025 12:00 PM | 2 | San Francisco 49ers | New Orleans Saints | 26 - 21 | Caesars Superdome | FOX |
| Sun, Sep 21 2025 3:25 PM | 3 | Arizona Cardinals | San Francisco 49ers | 15 - 16 | Levi's Stadium | FOX |
| Sun, Sep 28 2025 3:05 PM | 4 | Jacksonville Jaguars | San Francisco 49ers | 26 - 21 | Levi's Stadium | FOX |
| Thu, Oct 2 2025 7:15 PM | 5 | San Francisco 49ers | Los Angeles Rams | 26 - 23 | SoFi Stadium | Prime Video |
| Sun, Oct 12 2025 3:25 PM | 6 | San Francisco 49ers | Tampa Bay Buccaneers | - | Raymond James Stadium | CBS |
| Sun, Oct 19 2025 7:20 PM | 7 | Atlanta Falcons | San Francisco 49ers | - | Levi's Stadium | NBC |
| Sun, Oct 26 2025 12:00 PM | 8 | San Francisco 49ers | Houston Texans | - | NRG Stadium | FOX |
| Sun, Nov 2 2025 12:00 PM | 9 | San Francisco 49ers | New York Giants | - | MetLife Stadium | CBS |
| Sun, Nov 9 2025 3:25 PM | 10 | Los Angeles Rams | San Francisco 49ers | - | Levi's Stadium | FOX |
| Sun, Nov 16 2025 3:05 PM | 11 | San Francisco 49ers | Arizona Cardinals | - | State Farm Stadium | FOX |
| Mon, Nov 24 2025 7:15 PM | 12 | Carolina Panthers | San Francisco 49ers | - | Levi's Stadium | ESPN |
| Sun, Nov 30 2025 12:00 PM | 13 | San Francisco 49ers | Cleveland Browns | - | Huntington Bank Field | CBS |
| Sun, Dec 14 2025 3:25 PM | 15 | Tennessee Titans | San Francisco 49ers | - | Levi's Stadium | FOX |
| Mon, Dec 22 2025 7:15 PM | 16 | San Francisco 49ers | Indianapolis Colts | - | Lucas Oil Stadium | ESPN |
| Sun, Dec 28 2025 7:20 PM | 17 | Chicago Bears | San Francisco 49ers | - | Levi's Stadium | NBC |
| Sat, Jan 3 2026 11:00 PM | 18 | Seattle Seahawks | San Francisco 49ers | - | Levi's Stadium |